Perforin-2 (P2) is a pore-forming protein with cytotoxic activity against intracellular bacterial pathogens.P2 knockout (P2KO) mice are unable to control infections and die from normally non-lethal bacterial infections.Here we show that P2KO mice as compared to WT mice show significantly higher levels of systemic inflammation, measured by Tools inf
The increased use of electric arc furnace (EAF) steelmaking using up to 100% direct reduced iron (DRI) has prompted an interest in better control of phosphorus since iron ore and, consequently, DRI have higher phosphorus and silica compared to scrap.There is limited work reported on slag chemistries corresponding to that in the EAF when DRI is used
Abstract Objective To assess the efficacy of golimumab (GLM) as a treatment option for juvenile idiopathic arthritis (JIA)-associated uveitis refractory to adalimumab (ADA).Methods Retrospective single-centre study including patients with JIA receiving GLM for active uveitis after failing ADA.JIA- and uveitis-related data, including intraocular inf
The development of the DOTS Expansion Plan has been a milestone in tuberculosis (TB) control at the global and national levels.Key challenges that remain are overcoming the weakness of a strategy built on case Cups management, sustaining commitment, competing priorities, the threat of HIV, maintaining high quality of care and preventing drug resist